Bistability in Apoptosis: Roles of Bax, Bcl-2, and Mitochondrial Permeability Transition Pores
نویسندگان
چکیده
منابع مشابه
Response to bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores.
Recently, a mathematical model of the mitochondrial apoptotic pathway was proposed. In that study, the robustness of different simplified signaling models with respect to parameter changes was also investigated. It was found that bistability achieved via cooperative ultrasensitivity is ‘‘much more robust’’ than other mechanisms such as inhibitor ultrasensitivity. We reinvestigate this interesti...
متن کاملBistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores.
We propose a mathematical model for mitochondria-dependent apoptosis, in which kinetic cooperativity in formation of the apoptosome is a key element ensuring bistability. We examine the role of Bax and Bcl-2 synthesis and degradation rates, as well as the number of mitochondrial permeability transition pores (MPTPs), on the cell response to apoptotic stimuli. Our analysis suggests that cooperat...
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Apoptosis is of great importance in various biological systems for functioning of physiological processes in multicellular organisms. It is also required for normal functioning of the body, embryonic development , tissue homeostasis , functioning of immune system , removal of defective cells. Various factors take part in the process of apoptosis , the critical control point being regulated by t...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2006
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.068122